Walterboro is a city in Colleton County, South Carolina, United States. The city’s population was 5,398 at the 2010 census. It is the county seat of Colleton County. Walterboro is located 48 miles (77 km) west of Charleston and is located near the ACE Basin region in the South Carolina Lowcountry.

Walterboro (original spelling: Walterborough) was founded in 1783, as a summer retreat for local planters looking to escape their malaria-ridden, Lowcountry plantations. The original settlement was located on a hilly area, covered with pine and hickory trees and called Hickory Valley. Two of the earliest settlers were brothers, Paul and Jacob Walter. The brothers were prosperous, plantation owners, in nearby Jacksonboro. Paul’s small daughter Mary, was taken ill with malaria; a common disease among the families who had plantations in the marshy areas of the Lowcountry, due to the grounds suitability for rice production. To prevent Mary from succumbing to the deadly microbe, the Walter brothers went looking for a healthier location in which to live during the summer months, and came to settle the town; with its later being named in their honor.

In 1817, Walterboro was designated as the third county seat of Colleton County, and has remained such through present-day. This designation was followed by, the construction of a county courthouse and county jail in 1821. The courthouse was designed by well-known architect Robert Mills.

The town quickly spread from the original Hickory Valley location, after its population experienced a significant increase; this being fueled successively by, the town becoming the county seat in 1821, and the establishment of a railroad line that connected the city with Columbia and Charleston in the 1880s.

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